POS1441 SYMPTOMS CHARACTERISTICS OF SEROPOSITIVE INDIVIDUALS AT-RISK FOR DEVELOPING RHEUMATOID ARTHRITIS ARE VERSATILE AND COMPARABLE TO THOSE IN PEOPLE WITH EARLY RHEUMATOID ARTHRITIS

Background: The symptom burden of typical rheumatoid arthritis (RA) symptoms in those at risk for developing RA - positive anti-citrullinated peptide antibodies (ACPA) and musculoskeletal complaints has not been explored. Objectives: To evaluate patient-reported individuals at-risk to develop comparison people with newly diagnosed, early seropositive RA. Methods: Two datasources from the region Stockholm were used: RISK cohort follows up ACPA arthralgia, but without signs joint inflammation a structured program over 3 years. baseline visit this was used. Patients (ACPA and/or factor positive) (symptom duration 12 months maximum) reported Swedish Rheumatology Quality Register (SRQ) their closest diagnosis date before receiving DMARD treatment have identified. At-risk matched 1:3 by sex age using nearest neighbour method utilizing Mahalanobis distance, corrected sample bias exact matches on sex. Effect estimates being compared pain, patient global (GH), fatigue (all visual analogue scales), health assessment questionnaire (HAQ), TJC28 EuroQol-5D (EQ5D; range: 0-1) derived. Propensity score matching used as sensitivity analyses. Results: A total 223 820 patients. summary distribution variables effect differences between are shown Figure 1. show 24mm lower pain scores than This difference is even less (-17mm, 95%CI: -24 -11) when estimate additionally number tender joints. average 5.4 joints People 22mm GH (rate themselves better) 17mm Fatigue scored highest (mean:35mm, 30 29) among three VAS. HAQ 0.6 points EQ5D showed 0.24 higher index-values, outlining better status. Still mean only 0.74 (95%CI: 0.71 0.77), which values an age-matched general population (0.92 0.96). Sensitivity analyses revealed similar results. Boxplots health, fatigue, TJC28, HAQ, separately displayed at-risk. Population p<0.001) comparing provided every pair, 95% confidence interval brackets. Conclusion: Not surprisingly, report then diagnosed However, these range around minimal clinically important below, stresses need medical attention management strategies symptomatic individuals. Acknowledgements: study supported through New Horizon Fellowship FOREUM research fellowship grant part Innovative Medicines Initiative Joint Undertaking under agreement no 777357 (RTCure). Hensvold AH Catrina IA contributed equally. Disclosure Interests: None declared